UV spectrophotometric Dual wavelength method has been developed for simultaneous estimation of Drotaverine Hydrochloride and Diclofenac Potassium. The method involved measurement of absorbance difference at 262.0 nm and 287.6 nm (where Diclofenac potassium have same absorbance) and absorbance difference at 294 nm and 311.8 nm (where Drotaverine Hydrochloride have same absorbance) of Drotaverine Hydrochloride and Diclofenac Potassium respectively. Beer’s law obeyed in concentration range of 7-23 µg/ml and 4-20 µg/ml in distilled water for Drotaverine Hydrochloride and Diclofenac Potassium respectively. The percent assay of marketed formulation was 99.10% ± 0.5666 and 99.52% ± 1.3032 of Drotaverine Hydrochloride and Diclofenac Potassium respectively. The proposed methods are simple, accurate and precise since they are recommended for routine analysis.
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